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나노입자 연구단
나노입자 연구단
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Assessment of bevacizumab resistance increased by expression of BCAT1 in IDH1 wild-type glioblastoma: Application of DSC perfusion MR imaging

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Title
Assessment of bevacizumab resistance increased by expression of BCAT1 in IDH1 wild-type glioblastoma: Application of DSC perfusion MR imaging
Author(s)
Hye Rim Cho; Bora Hong; Kim H.; Park C.-K.; Park S.-H.; Park S.; Seung Hong Choi
Publication Date
2016-10
Journal
ONCOTARGET, v.7, no.43, pp.69606 - 69615
Publisher
IMPACT JOURNALS LLC
Abstract
BCAT1 (branched-chain amino acid trasaminase1) expression is necessary for the progression of IDH1 wild-type (WT) glioblastoma multiforme (GBM), which is known to be associated with aggressive tumors. The purpose of our study is to investigate the bevacizumab resistance increased by the expression of BCAT1 in IDH1 WT GBM in a rat model, which was evaluated using DSC perfusion MRI. BCAT1 sh#1 inhibits cell proliferation and limits cell migration potential in vitro. In vivo MRI showed that the increase in both tumor volume and nCBV after bevacizumab treatment in IDH1 WT tumors was significantly higher compared with BCAT1 sh#1tumors. In a histological analysis, more micro-vessel reformation by bevacizumab resistance was observed in IDH1 WT tumors than BCAT1 sh#1 tumors. These findings indicate that BCAT1 expression in IDH1 WT GBM increases resistance to bevacizumab treatment, which could be assessed by DSC perfusion MRI, and that nCBV can be a surrogate imaging biomarker for the prediction of antiangiogenic treatment in GBM.
URI
http://pr.ibs.re.kr/handle/8788114/3106
DOI
10.18632/oncotarget.11901
ISSN
1949-2553
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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