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나노입자 연구단
나노입자 연구단
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Electromechanical cardioplasty using a wrapped elasto-conductive epicardial mesh

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Title
Electromechanical cardioplasty using a wrapped elasto-conductive epicardial mesh
Author(s)
Jinkyung Park; Suji Choi; Janardhan A.H.; Lee S.-Y.; Raut S.; Soares J.; Kwangsoo Shin; Yang S.; Lee C.; Kang K.-W.; Hye Rim Cho; Seok Joo Kim; Pilseon Seo; Wonji Hyun; Sungmook Jung; Lee H.-J.; Lee N.; Seung Hong Choi; Sacks M.; Lu N.; Josephson M.E.; Taeghwan Hyeon; Dae-Hyeong Kim; Hwang H.J.
Publication Date
2016-06
Journal
SCIENCE TRANSLATIONAL MEDICINE, v.8, no.344, pp.344ra86 -
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Heart failure remains a major public health concern with a 5-year mortality rate higher than that of most cancers. Myocardial disease in heart failure is frequently accompanied by impairment of the specialized electrical conduction system and myocardium. We introduce an epicardial mesh made of electrically conductive and mechanically elastic material, to resemble the innate cardiac tissue and confer cardiac conduction system function, to enable electromechanical cardioplasty. Our epicardium-like substrate mechanically integrated with the heart and acted as a structural element of cardiac chambers. The epicardial device was designed with elastic properties nearly identical to the epicardial tissue itself and was able to detect electrical signals reliably on the moving rat heart without impeding diastolic function 8 weeks after induced myocardial infarction. Synchronized electrical stimulation over the ventricles by the epicardial mesh with the high conductivity of 11,210 S/cm shortened total ventricular activation time, reduced inherent wall stress, and improved several measures of systolic function including increases of 51% in fractional shortening, ∼90% in radial strain, and 42% in contractility. The epicardial mesh was also capable of delivering an electrical shock to terminate a ventricular tachyarrhythmia in rodents. Electromechanical cardioplasty using an epicardial mesh is a new pathway toward reconstruction of the cardiac tissue and its specialized functions. © 2016, American Association for the Advancement of Science. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/2761
ISSN
1946-6234
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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