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나노의학 연구단
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Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells

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Title
Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells
Author(s)
Ji-wook Kim; Jae-Hyun Lee; Ma, JH; Eunna Chung; Hongsuh Choi; Bok, J; Jinwoo Cheon
Publication Date
2016-06
Journal
NANO LETTERS, v.16, no.6, pp.3885 - 3891
Publisher
AMER CHEMICAL SOC
Abstract
Sound perception via mechano-sensation is a remarkably sensitive and fast transmission process, converting sound as a,mechanical input to neural signals in a living organism. Although knowledge of auditory hair cell-functions has advanced over the past decades, challenges remain in understanding their biornechatics, partly, because of their :biophysical complexity and the lack of appropriate probing tools. Most current studies of hair cells have been conducted in a relatively low-frequency range (<1000 Hz); therefore, fast kinetic study of hair cells has been difficult, even though mammalians have sound perception of 20 kHz or higher.. Here, Here, we demonstrate that the magnetic force nanoprobe (MFN) has superb spatiotemporal capabilities to mechanically stimulate spatially targeted individual hair cells with a temporal resolution of up to 9 its, which is equivalent to approximately SO :kHz; therefore, it possible. to investigate avian hair cell biomechanics at different tonotopic regions of the cochlea covering a full hearing frequency range of 50 to 5000 Hz. We, found that the variation of the stimulation frequency and amplitude of hair bundles creates distinct mechanical responsive features along the tonotopic axis, where the kinetics of the hair bundle recovery motion exhibits unique frequency-dependent characteristics: basal, middle, and apical hair bundles can effectively respond at their respective ranges of frequency. We revealed that such recovery kinetics possesses two different time constants that are closely related to the passive and active motilities of hair cells. The use of MFN is critical, for the kinetics study of free-standing hair cells in a spatiotemporally distinct tonotopic organization. © 2016 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2721
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > Journal Papers
Files in This Item:
acs.nanolett.6b01392_Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells.pdfDownload

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