BROWSE

Related Scientist

cn's photo.

cn
나노의학연구단
more info

ITEM VIEW & DOWNLOAD

Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells

DC Field Value Language
dc.contributor.authorJi-wook Kim-
dc.contributor.authorJae-Hyun Lee-
dc.contributor.authorMa, JH-
dc.contributor.authorEunna Chung-
dc.contributor.authorHongsuh Choi-
dc.contributor.authorBok, J-
dc.contributor.authorJinwoo Cheon-
dc.date.available2016-08-08T07:39:45Z-
dc.date.created2016-07-18-
dc.date.issued2016-06-
dc.identifier.issn1530-6984-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2721-
dc.description.abstractSound perception via mechano-sensation is a remarkably sensitive and fast transmission process, converting sound as a,mechanical input to neural signals in a living organism. Although knowledge of auditory hair cell-functions has advanced over the past decades, challenges remain in understanding their biornechatics, partly, because of their :biophysical complexity and the lack of appropriate probing tools. Most current studies of hair cells have been conducted in a relatively low-frequency range (<1000 Hz); therefore, fast kinetic study of hair cells has been difficult, even though mammalians have sound perception of 20 kHz or higher.. Here, Here, we demonstrate that the magnetic force nanoprobe (MFN) has superb spatiotemporal capabilities to mechanically stimulate spatially targeted individual hair cells with a temporal resolution of up to 9 its, which is equivalent to approximately SO :kHz; therefore, it possible. to investigate avian hair cell biomechanics at different tonotopic regions of the cochlea covering a full hearing frequency range of 50 to 5000 Hz. We, found that the variation of the stimulation frequency and amplitude of hair bundles creates distinct mechanical responsive features along the tonotopic axis, where the kinetics of the hair bundle recovery motion exhibits unique frequency-dependent characteristics: basal, middle, and apical hair bundles can effectively respond at their respective ranges of frequency. We revealed that such recovery kinetics possesses two different time constants that are closely related to the passive and active motilities of hair cells. The use of MFN is critical, for the kinetics study of free-standing hair cells in a spatiotemporally distinct tonotopic organization. © 2016 American Chemical Society-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectMagnetic nanoparticle-
dc.subjectmechanical force-
dc.subjectaudio frequency-
dc.subjectavian hair cell-
dc.subjecttonotopy-
dc.subjectbundle recovery time constant-
dc.titleMagnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000377642700068-
dc.identifier.scopusid2-s2.0-84974604025-
dc.identifier.rimsid56060ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorJi-wook Kim-
dc.contributor.affiliatedAuthorJae-Hyun Lee-
dc.contributor.affiliatedAuthorEunna Chung-
dc.contributor.affiliatedAuthorHongsuh Choi-
dc.contributor.affiliatedAuthorJinwoo Cheon-
dc.identifier.doi10.1021/acs.nanolett.6b01392-
dc.identifier.bibliographicCitationNANO LETTERS, v.16, no.6, pp.3885 - 3891-
dc.citation.titleNANO LETTERS-
dc.citation.volume16-
dc.citation.number6-
dc.citation.startPage3885-
dc.citation.endPage3891-
dc.date.scptcdate2018-10-01-
dc.description.wostc3-
dc.description.scptc3-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusMECHANOELECTRICAL TRANSDUCTION-
dc.subject.keywordPlusMECHANOTRANSDUCER CHANNEL-
dc.subject.keywordPlusCOCHLEAR AMPLIFICATION-
dc.subject.keywordPlusBULLFROGS SACCULUS-
dc.subject.keywordPlusADAPTATION-
dc.subject.keywordPlusBUNDLES-
dc.subject.keywordPlusOSCILLATIONS-
dc.subject.keywordPlusSENSITIVITY-
dc.subject.keywordPlusEAR-
dc.subject.keywordAuthorMagnetic nanoparticle-
dc.subject.keywordAuthormechanical force-
dc.subject.keywordAuthoraudio frequency-
dc.subject.keywordAuthoravian hair cell-
dc.subject.keywordAuthortonotopy-
dc.subject.keywordAuthorbundle recovery time constant-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
acs.nanolett.6b01392_Magnetic Force Nanoprobe for Direct Observation of Audio Frequency Tonotopy of Hair Cells.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse