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나노입자 연구단
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Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimeŕs Disease

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Title
Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimeŕs Disease
Author(s)
Hyek Jin Kwon; Cha M.-Y.; Dokyoon Kim; Kim D.K.; Min Soh; Kwangsoo Shin; Taeghwan Hyeon; Mook-Jung I.
Publication Date
2016-02
Journal
ACS NANO, v.10, no.2, pp.2860 - 2870
Publisher
AMER CHEMICAL SOC
Abstract
Mitochondrial oxidative stress is a key pathologic factor in neurodegenerative diseases, including Alzheimeŕs disease. Abnormal generation of reactive oxygen species (ROS), resulting from mitochondrial dysfunction, can lead to neuronal cell death. Ceria (CeO2) nanoparticles are known to function as strong and recyclable ROS scavengers by shuttling between Ce3+ and Ce4+ oxidation states. Consequently, targeting ceria nanoparticles selectively to mitochondria might be a promising therapeutic approach for neurodegenerative diseases. Here, we report the design and synthesis of triphenylphosphonium-conjugated ceria nanoparticles that localize to mitochondria and suppress neuronal death in a 5XFAD transgenic Alzheimeŕs disease mouse model. The triphenylphosphonium-conjugated ceria nanoparticles mitigate reactive gliosis and morphological mitochondria damage observed in these mice. Altogether, our data indicate that the triphenylphosphonium-conjugated ceria nanoparticles are a potential therapeutic candidate for mitochondrial oxidative stress in Alzheimeŕs disease. © 2016 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2624
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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