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면역 미생물 공생 연구단
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Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression

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Title
Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression
Author(s)
Jung-Hwan Kim; Eun-Ji Jeun; Chun-Pyo Hong; Kim SH; Min Seong Jang; Eun-Jung Lee; Sook Jin Moon; Chang Ho Yun; Sin-Hyeog Im; Jeong SG; Park BY; Kim KT; Seoh JY; Kim YK; Oh SJ; Ham JS; Bo-Gie Yang; Myoung Ho Jang
Publication Date
2016-02
Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.137, no.2, pp.507 - 516
Publisher
MOSBY-ELSEVIER
Abstract
Background: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms.Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies. (c) 2015 American Academy of Allergy, Asthma & Immunology
URI
https://pr.ibs.re.kr/handle/8788114/2394
ISSN
0091-6749
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
Files in This Item:
(2015)Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression.pdfDownload

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