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김정환
면역 미생물 공생 연구단
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Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression

DC Field Value Language
dc.contributor.authorJung-Hwan Kim-
dc.contributor.authorEun-Ji Jeun-
dc.contributor.authorChun-Pyo Hong-
dc.contributor.authorKim SH-
dc.contributor.authorMin Seong Jang-
dc.contributor.authorEun-Jung Lee-
dc.contributor.authorSook Jin Moon-
dc.contributor.authorChang Ho Yun-
dc.contributor.authorSin-Hyeog Im-
dc.contributor.authorJeong SG-
dc.contributor.authorPark BY-
dc.contributor.authorKim KT-
dc.contributor.authorSeoh JY-
dc.contributor.authorKim YK-
dc.contributor.authorOh SJ-
dc.contributor.authorHam JS-
dc.contributor.authorBo-Gie Yang-
dc.contributor.authorMyoung Ho Jang-
dc.date.available2016-02-23T08:27:07Z-
dc.date.created2015-10-12-
dc.date.issued2016-02-
dc.identifier.issn0091-6749-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2394-
dc.description.abstractBackground: The incidence of food allergies has increased dramatically during the last decade. Recently, probiotics have been studied for the prevention and treatment of allergic disease. Objective: We examined whether Bifidobacterium longum KACC 91563 and Enterococcus faecalis KACC 91532 have the capacity to suppress food allergies. Methods: B longum KACC 91563 and E faecalis KACC 91532 were administered to BALB/c wild-type mice, in which food allergy was induced by using ovalbumin and alum. Food allergy symptoms and various immune responses were assessed. Results: B longum KACC 91563, but not E faecalis KACC 91532, alleviated food allergy symptoms.Extracellular vesicles of B longum KACC 91563 bound specifically tomast cells and induced apoptosis without affecting T-cell immune responses. Furthermore, injection of family 5 extracellular solute-binding protein, a main component of extracellular vesicles, into micemarkedly reduced the occurrence of diarrhea in a mouse food allergy model. Conclusion: B longum KACC 91563 induces apoptosis of mast cells specifically and alleviates food allergy symptoms. Accordingly, B longum KACC 91563 and family 5 extracellular solute-binding protein exhibit potential as therapeutic approaches for food allergies. (c) 2015 American Academy of Allergy, Asthma & Immunology-
dc.languageENG-
dc.publisherMOSBY-ELSEVIER-
dc.titleExtracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000369235500020-
dc.identifier.scopusid2-s2.0-84957970327-
dc.description.wostc12-
dc.date.tcdate2018-10-01-
dc.date.scptcdate2018-10-01-
dc.subject.keywordFood allergy-
dc.subject.keywordBifidobacterium longum-
dc.subject.keywordprobiotics-
dc.subject.keywordextracellular vesicle-
dc.subject.keywordmast cells-
dc.subject.keywordfamily 5 extracellular solutebinding protein-
dc.subject.keywordovalbumin-
dc.contributor.affiliatedAuthorJung-Hwan Kim-
dc.contributor.affiliatedAuthorEun-Ji Jeun-
dc.contributor.affiliatedAuthorChang Ho Yun-
dc.contributor.affiliatedAuthorSin-Hyeog Im-
dc.contributor.affiliatedAuthorBo-Gie Yang-
dc.contributor.affiliatedAuthorMyoung Ho Jang-
dc.identifier.bibliographicCitationJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.137, no.2, pp.507 - 516-
dc.description.scptc17-
Appears in Collections:
Academy of Immunology and Microbiology(면역 미생물 공생 연구단) > Journal Papers (저널논문)
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(2015)Extracellular vesicle-derived protein from Bifidobacterium longum alleviates food allergy through mast cell suppression.pdfDownload

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