BROWSE

Related Scientist

Researcher

Tsvi Tlusty
첨단연성물질 연구단
more info

Binding of Transcription Factors Adapts to Resolve Information-Energy Tradeoff

Cited 2 time in webofscience Cited 0 time in scopus
409 Viewed 56 Downloaded
Title
Binding of Transcription Factors Adapts to Resolve Information-Energy Tradeoff
Author(s)
Yonatan Savir; Jacob Kagan; Tsvi Tlusty
Publication Date
2016-03
Journal
JOURNAL OF STATISTICAL PHYSICS, v.162, no.5, pp.1383 - 1394
Publisher
SPRINGER
Abstract
We examine the binding of transcription factors toDNAin terms of an information transfer problem. The input of the noisy channel is the biophysical signal of a factor bound to a DNA site, and the output is a distribution of probable DNA sequences at this site. This task involves an inherent tradeoff between the information gain and the energetics of the binding interaction—high binding energies provide higher information gain but hinder the dynamics of the system as factors are bound too tightly. We show that adaptation of the binding interaction towards increasing information transfer under a general energy constraint implies that the information gain per specific binding energy at each base-pair is maximized. We analyze hundreds of prokaryote and eukaryote transcription factors from various organisms to evaluate the discrimination energies.We find that, in accordance with our theoretical argument, binding energies nearly maximize the information gain per energy. This work suggests the adaptation of information gain as a generic design principle of molecular recognition systems. © Springer Science+Business Media New York 2015
URI
https://pr.ibs.re.kr/handle/8788114/2392
ISSN
0022-4715
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > Journal Papers (저널논문)
Files in This Item:
Binding of transcription factors adaps to resolve information-energy tradeoff.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse