An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment

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Title
An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment
Author(s)
Hyunjae Lee; Youngsik Lee; Changyeong Song; Hye Rim Cho; Ghaffari R.; Tae Kyu Choi; Kyung Hoon Kim; Young Bum Lee; Daishun Ling; Lee H.; Yu S.J.; Seung Hong Choi; Taeghwan Hyeon; Dae-Hyeong Kim
Publication Date
2015-11
Journal
NATURE COMMUNICATIONS, v.6, no., pp.10059 -
Publisher
NATURE PUBLISHING GROUP
Abstract
The gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions
URI
https://pr.ibs.re.kr/handle/8788114/2274
ISSN
2041-1723
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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