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Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing

Cited 43 time in webofscience Cited 43 time in scopus
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Title
Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing
Author(s)
Youngnam Kang; Jihoon Kim; Yeong Mi Lee; Sooseok Im; Park H.; Won Jong Kim
Subject
N-diazeniumdiolate, ; Nitric oxide, ; Ointment, ; Wound healing
Publication Date
2015-12
Journal
JOURNAL OF CONTROLLED RELEASE, v.220, pp.624 - 630
Publisher
ELSEVIER SCIENCE BV
Abstract
This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound. © 2015 Elsevier B.V. All rights reserved
URI
https://pr.ibs.re.kr/handle/8788114/2216
DOI
10.1016/j.jconrel.2015.08.057
ISSN
0168-3659
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
Y. N. Kang JCR 2015.pdfDownload

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