Evaluation of the microenvironmental heterogeneity in high-grade gliomas with IDH1/2 gene mutation using histogram analysis of diffusion-weighted imaging and dynamic-susceptibility contrast perfusion imaging
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- Evaluation of the microenvironmental heterogeneity in high-grade gliomas with IDH1/2 gene mutation using histogram analysis of diffusion-weighted imaging and dynamic-susceptibility contrast perfusion imaging
- Lee S.; Seung Hong Choi; Ryoo I.; Yoon T.J.; Kim T.M.; Lee S.-H.; Park C.-K.; Kim J.-H.; Sohn C.-H.; Park S.-H.; Kim I.H.
- JOURNAL OF NEURO-ONCOLOGY, v.121, no.1, pp.141 - 150
- The purpose of our study was to explore the
difference between isocitrate dehydrogenase (IDH)-1/2
gene mutation-positive and -negative high-grade gliomas
(HGGs) using histogram analysis of apparent diffusion
coefficient (ADC) and normalized cerebral blood volume
(nCBV) maps. We enrolled 52 patients with histopathologically
confirmed HGGs with IDH1/2P (n = 16) or
IDH1/2N (n = 36). Histogram parameters of ADC and
nCBV maps were correlated with gene mutations by using
the unpaired student’s t test and multivariable stepwise
logistic regression analysis. The mean ADC value was
higher in the IDH1P group than IDH1N (1,282.8 vs.
1,159.6 mm2/s, P = .0113). In terms of the cumulative
ADC histograms, the 10th and 50th percentile values were
also higher in the IDH1P than IDH1N (P = .0104 and
.0183, respectively). We observed a higher 90th percentile
value (3.121 vs. 2.397, P = .0208) and a steeper slope
between the 10th (C10) and 90th (C90) of cumulative
nCBV histograms (0.03386 vs. 0.02425/%, P = .0067) in
the IDH1N group. Multivariate analysis showed that the
mean ADC mean value (P = .0048), the C90 value
(P = .0113), and the slope between C10 and C90
(P = .0049) were the significant variables in the differentiation
of IDH1P from IDH1N. In conclusion, histogram
analysis of ADC and nCBV maps based on entire tumor
volume can be a useful tool for distinguishing IDH1P and
IDH1N, and it predicts that IDHP tumors have a more
heterogeneous microenvironment than IDHN ones.
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