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복잡계 자기조립 연구단
복잡계 자기조립 연구단
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Enhanced tumor-targeted gene delivery by bioreducible polyethylenimine tethering EGFR divalent ligands

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Title
Enhanced tumor-targeted gene delivery by bioreducible polyethylenimine tethering EGFR divalent ligands
Author(s)
Duhwan Lee; Yeong Mi Lee; Jihoon Kim; Lee, MK; Won Jong Kim
Publication Date
2015-03
Journal
BIOMATERIALS SCIENCE, v.3, no.7, pp.1096 - 1104
Abstract
This work demonstrates successful delivery of a gene to EGFR-overexpressed cancer cells by using a rationally designed branched GE11 peptide as a targeting ligand. In addition, we exploited the effect of the divalent structure of the branched GE11 peptide on the gene delivery and tumor targeting efficiency, compared to the monovalent GE11 peptide. The GE11 or branched GE11-tethered polymers were successfully synthesized. They are composed of a targeting peptide, disulfide crosslinked low molecular weight polyethylenimine and polyethylene glycol. Here, we evaluated the physicochemical properties, cytotoxicity and in vitro transfection efficiency and in vivo biodistribution of the GE11 and branched GE11 tethered polyplexes. Our results demonstrated that GE11 and bGE11-tethered gene delivery carriers showed efficient gene condensing ability, an enhanced transfection efficiency and targeting ability with low cytotoxicity. Interestingly, the branched GE11-tethered polymer showed the greater targeting ability to EGFR-overexpressed cancer cells in vivo than the GE11-tethered polymer. Therefore, this branched structure of targeting ligand has the potential for providing a novel strategy to design an efficient targeted delivery system
URI
https://pr.ibs.re.kr/handle/8788114/2092
ISSN
2047-4830
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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