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나노입자 연구단
나노입자 연구단
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Multifunctional cell-culture platform for aligned cell sheet monitoring, transfer printing, and therapy

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Title
Multifunctional cell-culture platform for aligned cell sheet monitoring, transfer printing, and therapy
Author(s)
Seok Joo Kim; Hye Rim Cho; Kyoung Won Cho; Qiao S.; Rhim J.S.; Min Soh; Taeho Kim; Moon Kee Choi; Changsoon Choi; Inhyuk Park; Hwang N.S.; Taeghwan Hyeon; Seung Hong Choi; Lu N.; Dae-Hyeong Kim
Publication Date
2015-03
Journal
ACS NANO, v.9, no.3, pp.2677 - 2688
Publisher
AMER CHEMICAL SOC
Abstract
While several functional platforms for cell culturing have been proposed for cell sheet engineering, a soft integrated system enabling in vitro physiological monitoring of aligned cells prior to their in vivo applications in tissue regeneration has not been reported. Here, we present a multifunctional, soft cell-culture platform equipped with ultrathin stretchable nanomembrane sensors and graphene-nanoribbon cell aligners, whose system modulus is matched with target tissues. This multifunctional platform is capable of aligning plated cells and in situ monitoring of cellular physiological characteristics during proliferation and differentiation. In addition, it is successfully applied as an in vitro muscle-on-A-chip testing platform. Finally, a simple but high-yield transfer printing mechanism is proposed to deliver cell sheets for scaffold-free, localized cell therapy in vivo. The muscle-mimicking stiffness of the platform allows the high-yield transfer printing of multiple cell sheets and results in successful therapies in diseased animal models. Expansion of current results to stem cells will provide unique opportunities for emerging classes of tissue engineering and cell therapy technologies. © 2015 American Chemical Society
URI
https://pr.ibs.re.kr/handle/8788114/2075
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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