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복잡계 자기조립 연구단
복잡계 자기조립 연구단
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RPM peptide conjugated bioreducible polyethylenimine targeting invasive colon cancer

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Title
RPM peptide conjugated bioreducible polyethylenimine targeting invasive colon cancer
Author(s)
Yeong Mi Lee; Duhwan Lee; Jihoon Kim; Park H.; Won Jong Kim
Publication Date
2015-05
Journal
JOURNAL OF CONTROLLED RELEASE, v.205, no., pp.172 - 180
Publisher
ELSEVIER SCIENCE BV
Abstract
CPIEDRPMC (RPM) peptide is a peptide that specifically targets invasive colorectal cancer, which is one of the leading causes of cancer-related deaths worldwide. In this study, we exploited RPM peptide as a targeting ligand to produce a novel and efficient gene delivery system that could potentially be used to treat invasive colon cancer. In order to achieve enhanced specificity to colon cancer cells, the RPM peptide was conjugated to a bioreducible gene carrier consisting of a reducible moiety of disulfide-crosslinked low molecular weight polyethylenimine, IR820 dye, and polyethylene glycol. Here, we examined the physiochemical properties, cytotoxicity, in vitro transfection efficiency, and in vivo biodistribution of the RPM-conjugated polyplex. Our results showed that the RPM-conjugated gene carrier formed a compact polyplex with pDNA that had low toxicity. Furthermore, the RPM-conjugated polymer not only had higher cellular uptake in invasive colon cancer than the non-targeted polymer, but also showed enhanced transfection efficiency in invasive colon cancer cells in vitro and in vivo. © 2015 Elsevier B.V
URI
https://pr.ibs.re.kr/handle/8788114/2019
ISSN
0168-3659
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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