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복잡계 자기조립 연구단
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Dynamic Release of Bending Stress in Short dsDNA by Formation of a Kink and Forks

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Title
Dynamic Release of Bending Stress in Short dsDNA by Formation of a Kink and Forks
Author(s)
Kim, C; Lee, OC; Kim, JY; Wokyung Sung; Lee, NK
Publication Date
2015-07
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.54, no.31, pp.8943 - 8947
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Bending with high curvature is one of the major mechanical properties of double-stranded DNA (dsDNA) that is essential for its biological functions. The emergence of a kink arising from local melting in the middle of dsDNA has been suggested as a mechanism of releasing the energy cost of bending. Herein, we report that strong bending induces two types of short dsDNA deformations, induced by two types of local melting, namely, a kink in the middle and forks at the ends, which we demonstrate using D-shaped DNA nanostructures. The two types of deformed dsDNA structures dynamically interconvert on a millisecond timescale. The transition from a fork to a kink is dominated by entropic contribution (anti-Arrhenius behavior), while the transition from a kink to a fork is dominated by enthalpic contributions. The presence of mismatches in dsDNA accelerates kink formation, and the transition from a kink to a fork is removed when the mismatch size is three base pairs
URI
https://pr.ibs.re.kr/handle/8788114/1982
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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