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나노 구조 물리 연구단
나노구조물리 연구단
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A size dependent evaluation of the cytotoxicity and uptake of nanographene oxide

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Title
A size dependent evaluation of the cytotoxicity and uptake of nanographene oxide
Author(s)
Mendes R.G.; Koch B.; Alicja Bachmatiuk; Ma X.; Sanchez S.; Damm C.; Schmidt O.G.; Gemming T.; Eckert J.; Mark H. Rummeli
Publication Date
2015-03
Journal
JOURNAL OF MATERIALS CHEMISTRY B, v.3, no.12, pp.2522 - 2529
Publisher
ROYAL SOC CHEMISTRYROYAL SOC CHEMISTRY
Abstract
Graphene oxide (GO) has attracted great interest due to its extraordinary potential for biomedical application. Although it is clear that the naturally occurring morphology of biological structures is crucial to their precise interactions and correct functioning, the geometrical aspects of nanoparticles are often ignored in the design of nanoparticles for biological applications. A few in vitro and in vivo studies have evaluated the cytotoxicity and biodistribution of GO, however very little is known about the influence of flake size and cytotoxicity. Herein, we aim at presenting an initial cytotoxicity evaluation of different nano-sized GO flakes for two different cell lines (HeLa (Kyoto) and macrophage (J7742)) when they are exposed to samples containing different sized nanographene oxide (NGO) flakes (mean diameter of 89 and 277 nm). The obtained data suggests that the larger NGO flakes reduce cell viability as compared to smaller flakes. In addition, the viability reduction correlates with the time and the concentration of the NGO nanoparticles to which the cells are exposed. Uptake studies were also conducted and the data suggests that both cell lines internalize the GO nanoparticles during the incubation periods studied. © 2015 The Royal Society of Chemistry
URI
https://pr.ibs.re.kr/handle/8788114/1806
ISSN
2050-750X
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > Journal Papers (저널논문)
Files in This Item:
A Size dependent_J. Mater. Chem. B(Mark).pdfDownload

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