BROWSE

Related Scientist

Researcher

RNA 연구단
RNA 연구단
more info

Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells

Cited 10 time in webofscience Cited 0 time in scopus
1,564 Viewed 2,957 Downloaded
Title
Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells
Author(s)
Boo K.; Bhin J.; Jeon Y.; Kim J.; Shin H.-J.R.; Jong-Eun Park; Kim K.; Kim C.R.; Jang H.; Kim I.-H.; V.Narry Kim; Daehee Hwang; Lee H.; Baek S.H.
Publication Date
2015-04
Journal
NATURE COMMUNICATIONS, v.6, no., pp.6810 -
Publisher
NATURE PUBLISHING GROUP
Abstract
The actions of transcription factors, chromatin modifiers and noncoding RNAs are crucial for the programming of cell states. Although the importance of various epigenetic machineries for controlling pluripotency of embryonic stem (ES) cells has been previously studied, how chromatin modifiers cooperate with specific transcription factors still remains largely elusive. Here, we find that Pontin chromatin remodelling factor plays an essential role as a coactivator for Oct4 for maintenance of pluripotency in mouse ES cells. Genome-wide analyses reveal that Pontin and Oct4 share a substantial set of target genes involved in ES cell maintenance. Intriguingly, we find that the Oct4-dependent coactivator function of Pontin extends to the transcription of large intergenic noncoding RNAs (lincRNAs) and in particular linc1253, a lineage programme repressing lincRNA, is a Pontin-dependent Oct4 target lincRNA. Together, our findings demonstrate that the Oct4-Pontin module plays critical roles in the regulation of genes involved in ES cell fate determination. © 2015 Macmillan Publishers Limited. All rights reserved
URI
http://pr.ibs.re.kr/handle/8788114/1681
DOI
10.1038/ncomms7810
ISSN
2041-1723
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
Files in This Item:
ncomms7810.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse