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Pontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cells

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dc.contributor.authorBoo K.ko
dc.contributor.authorBhin J.ko
dc.contributor.authorJeon Y.ko
dc.contributor.authorKim J.ko
dc.contributor.authorShin H.-J.R.ko
dc.contributor.authorJong-Eun Parkko
dc.contributor.authorKim K.ko
dc.contributor.authorKim C.R.ko
dc.contributor.authorJang H.ko
dc.contributor.authorKim I.-H.ko
dc.contributor.authorV.Narry Kimko
dc.contributor.authorDaehee Hwangko
dc.contributor.authorLee H.ko
dc.contributor.authorBaek S.H.ko
dc.date.available2015-06-29T08:20:31Z-
dc.date.created2015-05-18ko
dc.date.issued201504ko
dc.identifier.issn2041-1723ko
dc.identifier.urihttp://pr.ibs.re.kr/handle/8788114/1681ko
dc.description.abstractThe actions of transcription factors, chromatin modifiers and noncoding RNAs are crucial for the programming of cell states. Although the importance of various epigenetic machineries for controlling pluripotency of embryonic stem (ES) cells has been previously studied, how chromatin modifiers cooperate with specific transcription factors still remains largely elusive. Here, we find that Pontin chromatin remodelling factor plays an essential role as a coactivator for Oct4 for maintenance of pluripotency in mouse ES cells. Genome-wide analyses reveal that Pontin and Oct4 share a substantial set of target genes involved in ES cell maintenance. Intriguingly, we find that the Oct4-dependent coactivator function of Pontin extends to the transcription of large intergenic noncoding RNAs (lincRNAs) and in particular linc1253, a lineage programme repressing lincRNA, is a Pontin-dependent Oct4 target lincRNA. Together, our findings demonstrate that the Oct4-Pontin module plays critical roles in the regulation of genes involved in ES cell fate determination. © 2015 Macmillan Publishers Limited. All rights reservedko
dc.languageENGko
dc.publisherNATURE PUBLISHING GROUPko
dc.titlePontin functions as an essential coactivator for Oct4-dependent lincRNA expression in mouse embryonic stem cellsko
dc.typeARTICLEko
dc.type.rimsAko
dc.identifier.wosid000353702500050ko
dc.identifier.scopusid2-s2.0-84927637015ko
dc.identifier.pid380null
dc.identifier.pid498null
dc.identifier.pid375null
dc.description.wostc10-
dc.date.scptcdate2018-10-01-
dc.identifier.doi10.1038/ncomms7810ko
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, v.6, no., pp.6810 -ko
dc.date.tcdate2018-10-01-
dc.description.scptc13-
dc.type.docTypeArticle-
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > Journal Papers (저널논문)
Center for RNA Research(RNA 연구단) > Journal Papers (저널논문)
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