Supramolecular hydrogels for long-term bioengineered stem cell therapy

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Title
Supramolecular hydrogels for long-term bioengineered stem cell therapy
Author(s)
Yeom J.; Kim S.J.; Jung H.; Namkoong H.; Yang J.; Hwang B.W.; Kyunghoon Oh; Kimoon Kim; Sung Y.C.; Hahn S.K.
Publication Date
2015-01
Journal
ADVANCED HEALTHCARE MATERIALS, v.4, no.2, pp.237 - 244
Abstract
Synthetic hydrogels have been extensively investigated as artifi cial extracellular matrices (ECMs) for tissue engineering in vitro and in vivo. Crucial challenges for such hydrogels are sustaining long-term cytocompatible encapsulation and providing appropriate cues at the right place and time for spatiotemporal control of the cells. Here, in situ supramolecularly assembled and modularly modifi ed hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy are reported using cucurbit[6]uril-conjugated hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug-conjugated CB[6] (drug-CB[6]). The eMSCs producing enhanced green fl uorescence protein (EGFP) remain alive and emit the fl uorescence within CB[6]/DAH-HA hydrogels in mice for more than 60 d. Furthermore, the long-term expression of mutant interleukin-12 (IL-12M) by eMSCs within the supramolecular hydrogels results in effective inhibition of tumor growth with a signifi cantly enhanced survival rate. Taken together, these fi ndings confi rm the feasibility of supramolecular HA hydrogels as 3D artifi cial ECMs for cell therapies and tissue engineering applications.
URI
https://pr.ibs.re.kr/handle/8788114/1637
ISSN
2192-2640
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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