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Neuropathogenesis-on-chips for neurodegenerative diseases

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Title
Neuropathogenesis-on-chips for neurodegenerative diseases
Author(s)
Amartumur, Sarnai; Nguyen, Huong; Huynh, Thuy; Testaverde S. Kim; Woo, Ran-Sook; Oh, Eungseok; Kim, Kyeong Kyu; Lee, Luke P.; Chaejeong Heo
Publication Date
2024-03
Journal
Nature Communications, v.15, no.1
Publisher
Nature Research
Abstract
Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs. © The Author(s) 2024.
URI
https://pr.ibs.re.kr/handle/8788114/15197
DOI
10.1038/s41467-024-46554-8
ISSN
2041-1723
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > 1. Journal Papers (저널논문)
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