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The ergodicity question when imaging DNA conformation using liquid cell electron microscopy

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Title
The ergodicity question when imaging DNA conformation using liquid cell electron microscopy
Author(s)
Li, Jia-Ye; Liu, Fan; Xu, Jing; Ye-Jin Kim; Oh-Hoon Kwon; Xia, Bin; Wang, Huan; Steve Granick
Publication Date
2024-01
Journal
Proceedings of the National Academy of Sciences of the United States of America, v.121, no.3
Abstract
Assessing the ergodicity of graphene liquid cell electron microscope measurements, we report that loop states of circular DNA interconvert reversibly and that loop numbers follow the Boltzmann distribution expected for this molecule in bulk solution, provided that the electron dose is low (80-keV electron energy and electron dose rate 1-20 e- Å-2 s-1). This imaging technique appears to act as a slow motion camera that reveals equilibrated distributions by imaging the time average of a few molecules without the need to image a spatial ensemble.
URI
https://pr.ibs.re.kr/handle/8788114/14714
DOI
10.1073/pnas.2314797121
ISSN
0027-8424
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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