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Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment

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Title
Long-term cargo tracking reveals intricate trafficking through active cytoskeletal networks in the crowded cellular environment
Author(s)
Jin-Sung Park; Il-Buem Lee; Hyeon-Min Moon; Seok-Cheol Hong; Minhaeng Cho
Publication Date
2023-11
Journal
Nature Communications, v.14, no.1
Publisher
Nature Research
Abstract
A eukaryotic cell is a microscopic world within which efficient material transport is essential. Yet, how a cell manages to deliver cellular cargos efficiently in a crowded environment remains poorly understood. Here, we used interferometric scattering microscopy to track unlabeled cargos in directional motion in a massively parallel fashion. Our label-free, cargo-tracing method revealed not only the dynamics of cargo transportation but also the fine architecture of the actively used cytoskeletal highways and the long-term evolution of the associated traffic at sub-diffraction resolution. Cargos frequently run into a blocked road or experience a traffic jam. Still, they have effective strategies to circumvent those problems: opting for an alternative mode of transport and moving together in tandem or migrating collectively. All taken together, a cell is an incredibly complex and busy space where the principle and practice of transportation intriguingly parallel those of our macroscopic world. © 2023, The Author(s).
URI
https://pr.ibs.re.kr/handle/8788114/14573
DOI
10.1038/s41467-023-42347-7
ISSN
2041-1723
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > 1. Journal Papers (저널논문)
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