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Visible-light-driven photocatalysis for the sustainable synthesis of (±)-pregabalin using carbon nitride from melamine-cyanuric acid complex

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Title
Visible-light-driven photocatalysis for the sustainable synthesis of (±)-pregabalin using carbon nitride from melamine-cyanuric acid complex
Author(s)
Kim, Sumin; Choi, Hyunwoo; Kwak, Minjoon; Seo, Youngran; Dongwon Yoo
Publication Date
2023-12
Journal
Nano Trends, v.4
Publisher
Elsevier BV
Abstract
The pharmaceutical industry has long sought efficient and environmentally sustainable methods for the synthesis of pharmaceutically significant molecules, particularly potent γ-amino butyric acid (GABA) derivatives. Photocatalysis has emerged as a promising approach, offering mild reaction conditions and utilizing renewable energy sources. In this study, we present a novel and sustainable photocatalytic strategy for the synthesis of (±)-pregabalin, a valuable GABA derivative, using carbon nitride derived from the complex of melamine and cyanuric acid (CN-MC) as the catalyst. Under visible light irradiation, CN-MC demonstrated outstanding photocatalytic performance, achieving an excellent 99% yield in the visible-light-driven decarboxylative radical conjugate addition. The formed β-substituted γ-lactam intermediate serves as a crucial building block for the synthesis of (±)-pregabalin. Moreover, the recyclability and scalability of CN-MC as a photocatalyst enhance the process's eco-friendliness, making it an appealing option for large-scale pharmaceutical synthesis.
URI
https://pr.ibs.re.kr/handle/8788114/14541
DOI
10.1016/j.nwnano.2023.100026
ISSN
2666-9781
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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