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복잡계자기조립연구단
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Magnetically Enhanced Intracellular Uptake of Superparamagnetic Iron Oxide Nanoparticles for Antitumor Therapy

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Title
Magnetically Enhanced Intracellular Uptake of Superparamagnetic Iron Oxide Nanoparticles for Antitumor Therapy
Author(s)
Choi, Junhee; Kim, Dong-In; Kim, Jin-Young; Pane, Salvador; Nelson, Bradley J.; Young-Tae Chang; Choi, Hongsoo
Publication Date
2023-07
Journal
ACS NANO, v.17, no.16, pp.15857 - 15870
Publisher
AMER CHEMICAL SOC
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) havebeen widelyemployed in biomedical fields, including targeted delivery of antitumortherapy. Conventional magnetic tumor targeting has used simple staticmagnetic fields (SMFs), which cause SPIONs to linearly aggregate intoa long chain-like shape. Such agglomeration greatly hinders the intracellulartargeting of SPIONs into tumors, thus reducing the therapeutic efficacy.In this study, we investigated the enhancement of the intracellularuptake of SPIONs through the application of rotating magnetic fields(RMFs). Based on the physical principles of SPION chain disassembly,we investigated physical parameters to predict the chain length favorablefor intracellular uptake. Our prediction was validated by clear visualizationof the intracellular distributions of SPIONs in tumor cells at bothcellular and three-dimensional microtissue levels.To identify the potential therapeutic effects of enhanced intracellularuptake, magnetic hyperthermia as antitumor therapy was investigatedunder varying conditions of magnetic hyperthermia and RMFs. The resultsshowed that enhanced intracellular uptake reduced magnetic hyperthermiatime and strength as well as particle concentration. The proposedmethod will be useful in the development of techniques to determinethe optimized physical conditions for the enhanced intracellular uptakeof SPIONs in antitumor therapy.
URI
https://pr.ibs.re.kr/handle/8788114/13925
DOI
10.1021/acsnano.3c03780
ISSN
1936-0851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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