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High-resolution three-photon biomedical imaging using doped ZnS nanocrystals

Cited 167 time in webofscience Cited 191 time in scopus
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Title
High-resolution three-photon biomedical imaging using doped ZnS nanocrystals
Author(s)
Jung Ho Yu; Kwon, Seung-Hae; Petrasek, Zdenek; Park, Ok Kyu; Samuel Woojoo Jun; Kwangsoo Shin; Moon Kee Choi; Yong Il Park; Park, Kyeongsoon; Hyon Bin Na; Nohyun Lee; Dong Won Lee; Jeong Hyun Kim; Schwille, Petra; Taeg Hwan Hyeon
Subject
Biomedical imaging, ; Clinical application, ; High spatial resolution, ; Imaging applications, ; Nanocrystal doping, ; Theoretical limits, ; Three-photon excitation, ; Visible emissions, ; Biocompatibility, ; Doping (additives), ; Medical imaging, ; Nanocrystals, ; Photons, ; Zinc sulfide, ; Multiphoton processes, ; manganese, ; nanoparticle, ; sulfide, ; zinc derivative, ; zinc sulfide, ; article, ; chemistry, ; human, ; image quality, ; photon, ; tumor cell culture, ; Humans, ; Manganese, ; Nanoparticles, ; Phantoms, Imaging, ; Photons, ; Sulfides, ; Tumor Cells, Cultured, ; Zinc Compounds
Publication Date
2013-04
Journal
NATURE MATERIALS, v.12, no.4, pp.359 - 366
Publisher
NATURE PUBLISHING GROUP
Abstract
Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn 2+ dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging. © 2013 Macmillan Publishers Limited. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/1349
DOI
10.1038/NMAT3565
ISSN
1476-1122
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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