BROWSE

Related Scientist

Researcher

나노입자 연구단
나노입자 연구단
more info

High-resolution three-photon biomedical imaging using doped ZnS nanocrystals Highly Cited Paper

Cited 133 time in webofscience Cited 0 time in scopus
375 Viewed 45 Downloaded
Title
High-resolution three-photon biomedical imaging using doped ZnS nanocrystals
Author(s)
Jung Ho Yu; Kwon, Seung-Hae; Petrasek, Zdenek; Park, Ok Kyu; Samuel Woojoo Jun; Kwangsoo Shin; Moon Kee Choi; Yong Il Park; Park, Kyeongsoon; Hyon Bin Na; Nohyun Lee; Dong Won Lee; Jeong Hyun Kim; Schwille, Petra; Taeg Hwan Hyeon
Publication Date
2013-04
Journal
NATURE MATERIALS, v.12, no.4, pp.359 - 366
Publisher
NATURE PUBLISHING GROUP
Abstract
Three-photon excitation is a process that occurs when three photons are simultaneously absorbed within a luminophore for photo-excitation through virtual states. Although the imaging application of this process was proposed decades ago, three-photon biomedical imaging has not been realized yet owing to its intrinsic low quantum efficiency. We herein report on high-resolution in vitro and in vivo imaging by combining three-photon excitation of ZnS nanocrystals and visible emission from Mn 2+ dopants. The large three-photon cross-section of the nanocrystals enabled targeted cellular imaging under high spatial resolution, approaching the theoretical limit of three-photon excitation. Owing to the enhanced Stokes shift achieved through nanocrystal doping, the three-photon process was successfully applied to high-resolution in vivo tumour-targeted imaging. Furthermore, the biocompatibility of ZnS nanocrystals offers great potential for clinical applications of three-photon imaging. © 2013 Macmillan Publishers Limited. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/1349
ISSN
1476-1122
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
4. High-resolution three-photon biomedical imaging.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse