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Ventricular tachyarrhythmia treatment and prevention by subthreshold stimulation with stretchable epicardial multichannel electrode array

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Title
Ventricular tachyarrhythmia treatment and prevention by subthreshold stimulation with stretchable epicardial multichannel electrode array
Author(s)
Sung-Hyuk Sunwoo; Cha, Myung-Jin; Sang Ihn Han; Hyejeong Kang; Cho, Ye Seul; Yeom, Da-Hae; Park, Chan Soon; Park, Na Kyeong; Choi, Seong Woo; Kim, Sung Joon; Gi Doo Cha; Dongjun Jung; Suji Choi; Oh, Seil; Nam, Gi-Byoung; Taeghwan Hyeon; Dae-Hyeong Kim; Seung-Pyo Lee
Publication Date
2023-03
Journal
Science advances, v.9, no.13, pp.eadf6856
Publisher
NLM (Medline)
Abstract
The implantable cardioverter-defibrillator (ICD) is an effective method to prevent sudden cardiac death in high-risk patients. However, the transvenous lead is incompatible with large-area electrophysiological mapping and cannot accommodate selective multichannel precision stimulations. Moreover, it involves high-energy shocks, resulting in pain, myocardial damage, and recurrences of ventricular tachyarrhythmia (VTA). We present a method for VTA treatment based on subthreshold electrical stimulations using a stretchable epicardial multichannel electrode array, which does not disturb the normal contraction or electrical propagation of the ventricle. In rabbit models with myocardial infarction, the infarction was detected by mapping intracardiac electrograms with the stretchable epicardial multichannel electrode array. Then, VTAs could be terminated by sequential electrical stimuli from the epicardial multichannel electrode array beginning with low-energy subthreshold stimulations. Last, we used these subthreshold stimulations to prevent the occurrence of additional VTAs. The proposed protocol using the stretchable epicardial multichannel electrode array provides opportunities toward the development of innovative methods for painless ICD therapy.
URI
https://pr.ibs.re.kr/handle/8788114/13412
DOI
10.1126/sciadv.adf6856
ISSN
2375-2548
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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