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Modulation of transmembrane anion transport of porphyrin boxes by dynamic window size engineering

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Title
Modulation of transmembrane anion transport of porphyrin boxes by dynamic window size engineering
Author(s)
Hong-Guen Lee; Avinash Dhamija; Kimoon Kim
Publication Date
2023-01
Journal
Journal of Porphyrins and Phthalocyanines, v.27, no.01n04, pp.268 - 273
Publisher
World Scientific
Abstract
The development of synthetic transmembrane anion transport systems is of considerable interest, not only for mimicking the functions of natural transmembrane proteins but also for practical applications. We have recently reported a porous organic cage, porphyrin box (PB(8)) having multiple windows surrounded by octyl chains as an iodide selective anion channel. Herein, we report the modulation of transmembrane transport of halides (Cl-, Br-, and I-) by dynamic window size engineering of the cage with different alkyl chain lengths (hexyl PB(6), octyl PB(8) and decyl PB(10)). 'Apparent' transport rates were measured by the HPTS fluorescence assay, which shows a gradual decrease in the transport rate upon increasing the length of alkyl chains of PB. We calculate the transport rate per PB in order to make a fair comparison as the 'apparent' transport rate is proportional to the number of PBs embedded in the lipid membrane. The transport rate per PB reveals that increasing the length of the alkyl chains of PBs results in a substantial fall in the iodide transport rate while only marginally decreasing the transport rates of bromide and chloride, thereby decreasing the selectivity of iodide transport. © 2022 World Scientific Publishing Company.
URI
https://pr.ibs.re.kr/handle/8788114/13367
DOI
10.1142/S1088424622500894
ISSN
1088-4246
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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