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Nano-Sized CT Contrast Agents Highly Cited Paper

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Title
Nano-Sized CT Contrast Agents
Author(s)
Nohyun Lee; Seung Hong Choi; Taeg Hwan Hyeon
Publication Date
2013-05
Journal
ADVANCED MATERIALS, v.25, no.19, pp.2641 - 2660
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Computed tomography (CT) is one of the most widely used clinical imaging modalities. In order to increase the sensitivity of CT, small iodinated compounds are used as injectable contrast agents. However, the iodinated contrast agents are excreted through the kidney and have short circulation times. This rapid renal clearance not only restricts in vivo applications that require long circulation times but also sometimes induces serious adverse effects related to the excretion pathway. In addition, the X-ray attenuation of iodine is not effi cient for clinical CT that uses high-energy X-ray. Due to these limitations, nano-sized iodinated CT contrast agents have been developed that can increase the circulation time and decrease the adverse effects. In addition to iodine, nanoparticles based on heavy atoms such as gold, lanthanides, and tantalum are used as more effi cient CT contrast agents. In this review, we summarize the recent progresses made in nano-sized CT contrast agents.
URI
https://pr.ibs.re.kr/handle/8788114/1325
ISSN
0935-9648
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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