T-type Ca2+ channels in absence epilepsy

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Title
T-type Ca2+ channels in absence epilepsy
Author(s)
Eunji Cheong; Hee-Sup Shin
Publication Date
2013-07
Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v.1828, no.7, pp.1560 - 1571
Publisher
ELSEVIER SCIENCE BV
Abstract
Low-voltage-activated T-type Ca2+ channels are highly expressed in the thalamocortical circuit, suggesting that they play a role in this brain circuit. Indeed, low-threshold burst firing mediated by T-type Ca2+ channels has long been implicated in the synchronization of the thalamocortical circuit. Over the past few decades, the conventional view has been that rhythmic burst firing mediated by T-type channels in both thalamic reticular nuclie (TRN) and thalamocortical (TC) neurons are equally critical in the generation of thalamocortical oscillations during sleep rhythms and spike-wave-discharges (SWDs). This review broadly investigates recent studies indicating that even though both TRN and TC nuclei are required for thalamocortical oscillations, the contributions of T-type channels to TRN and TC neurons are not equal in the genesis of sleep spindles and SWDs. T-type channels in TC neurons are an essential component of SWD generation, whereas the requirement for TRN T-type channels in SWD generation remains controversial at least in the GBLmodel of absence seizures. Therefore, a deeper understanding of the functional consequences ofmodulating each T-type channel subtype could guide the development of therapeutic tools for absence seizures while minimizing side effects on physiological thalamocortical oscillations. This article is part of a Special Issue entitled: Calcium channels. © 2013 Elsevier B.V. All rights reserved.
URI
https://pr.ibs.re.kr/handle/8788114/1286
ISSN
0005-2736
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > Journal Papers (저널논문)
Files in This Item:
2013-07-01-Biochimica et Biophysica Acta-Biomembranes-T-type.pdfDownload

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