BROWSE

Related Scientist

shin,heesup's photo.

shin,heesup
사회성뇌과학그룹
more info

ITEM VIEW & DOWNLOAD

T-type Ca2+ channels in absence epilepsy

DC Field Value Language
dc.contributor.authorEunji Cheong-
dc.contributor.authorHee-Sup Shin-
dc.date.available2015-04-20T06:50:28Z-
dc.date.created2014-08-11-
dc.date.issued2013-07-
dc.identifier.issn0005-2736-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1286-
dc.description.abstractLow-voltage-activated T-type Ca2+ channels are highly expressed in the thalamocortical circuit, suggesting that they play a role in this brain circuit. Indeed, low-threshold burst firing mediated by T-type Ca2+ channels has long been implicated in the synchronization of the thalamocortical circuit. Over the past few decades, the conventional view has been that rhythmic burst firing mediated by T-type channels in both thalamic reticular nuclie (TRN) and thalamocortical (TC) neurons are equally critical in the generation of thalamocortical oscillations during sleep rhythms and spike-wave-discharges (SWDs). This review broadly investigates recent studies indicating that even though both TRN and TC nuclei are required for thalamocortical oscillations, the contributions of T-type channels to TRN and TC neurons are not equal in the genesis of sleep spindles and SWDs. T-type channels in TC neurons are an essential component of SWD generation, whereas the requirement for TRN T-type channels in SWD generation remains controversial at least in the GBLmodel of absence seizures. Therefore, a deeper understanding of the functional consequences ofmodulating each T-type channel subtype could guide the development of therapeutic tools for absence seizures while minimizing side effects on physiological thalamocortical oscillations. This article is part of a Special Issue entitled: Calcium channels. © 2013 Elsevier B.V. All rights reserved.-
dc.description.uri1-
dc.language영어-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectT-type Ca2+ channel Absence epilepsy Thalamocortical circuit Burst firing Oscillations-
dc.titleT-type Ca2+ channels in absence epilepsy-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000318826700006-
dc.identifier.scopusid2-s2.0-84876906339-
dc.identifier.rimsid7ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorHee-Sup Shin-
dc.identifier.doi10.1016/j.bbamem.2013.02.002-
dc.identifier.bibliographicCitationBIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, v.1828, no.7, pp.1560 - 1571-
dc.citation.titleBIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES-
dc.citation.volume1828-
dc.citation.number7-
dc.citation.startPage1560-
dc.citation.endPage1571-
dc.date.scptcdate2018-10-01-
dc.description.wostc19-
dc.description.scptc18-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
2013-07-01-Biochimica et Biophysica Acta-Biomembranes-T-type.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse