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TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism

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Title
TRPV4 acts as a mitochondrial Ca2+-importer and regulates mitochondrial temperature and metabolism
Author(s)
Kanta Acharya, Tusar; Kumar, Ashutosh; Kumar Majhi, Rakesh; Kumar, Shamit; Chakraborty, Ranabir; Tiwari, Ankit; Smalla, Karl-Heinz; Xiao Liu; Young-Tae Chang; Gundelfinger, Eckart D.; Goswami, Chandan
Publication Date
2022-11
Journal
Mitochondrion, v.67, pp.38 - 58
Publisher
Elsevier B.V.
Abstract
© 2022 Elsevier B.V. and Mitochondria Research SocietyTRPV4 is associated with the development of neuropathic pain, sensory defects, muscular dystrophies, neurodegenerative disorders, Charcot Marie Tooth and skeletal dysplasia. In all these cases, mitochondrial abnormalities are prominent. Here, we demonstrate that TRPV4, localizes to a subpopulation of mitochondria in various cell lines. Improper expression and/or function of TRPV4 induces several mitochondrial abnormalities. TRPV4 is also involved in the regulation of mitochondrial numbers, Ca2+-levels and mitochondrial temperature. Accordingly, several naturally occurring TRPV4 mutations affect mitochondrial morphology and distribution. These findings may help in understanding the significance of mitochondria in TRPV4-mediated channelopathies possibly classifying them as mitochondrial diseases.
URI
https://pr.ibs.re.kr/handle/8788114/12583
DOI
10.1016/j.mito.2022.10.001
ISSN
1567-7249
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
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