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Human mini-blood–brain barrier models for biomedical neuroscience research: a review

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Title
Human mini-blood–brain barrier models for biomedical neuroscience research: a review
Author(s)
Tran, Minh; Chaejeong Heo; Lee, Luke P.; Cho, Hansang
Publication Date
2022-12
Journal
Biomaterials Research, v.26, no.1
Publisher
BioMed Central Ltd
Abstract
© 2022, The Author(s).The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements in creating in vitro human BBB platforms, challenges in generating specifics of physiopathological relevance are viewed as impediments to the establishment of in vitro models. In this review, we provide insight into the development and deployment of in vitro BBB models that allow investigation of the physiology and pathology of neurological therapeutic avenues. First, we highlight the critical components, including cell sources, biomaterial glue collections, and engineering techniques to reconstruct a miniaturized human BBB. Second, we describe recent breakthroughs in human mini-BBBs for investigating biological mechanisms in neurology. Finally, we discuss the application of human mini-BBBs to medical approaches. This review provides strategies for understanding neurological diseases, a validation model for drug discovery, and a potential approach for generating personalized medicine.
URI
https://pr.ibs.re.kr/handle/8788114/12485
DOI
10.1186/s40824-022-00332-z
ISSN
1226-4601
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > 1. Journal Papers (저널논문)
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