BROWSE

Related Scientist

CSC's photo.

CSC
복잡계 자기조립 연구단
more info

ITEM VIEW & DOWNLOAD

Synthetic Monosaccharide Channels: Size-Selective Transmembrane Transport of Glucose and Fructose Mediated by Porphyrin Boxes

Cited 0 time in webofscience Cited 0 time in scopus
217 Viewed 0 Downloaded
Title
Synthetic Monosaccharide Channels: Size-Selective Transmembrane Transport of Glucose and Fructose Mediated by Porphyrin Boxes
Author(s)
Hong-Guen Lee; Avinash Dhamija; Das, Chandan K.; Park, Kyeng Min; Young-Tae Chang; Schäfer, Lars V.; Kimoon Kim
Publication Date
2023-01
Journal
Angewandte Chemie - International Edition, v.62, no.2
Publisher
John Wiley and Sons Inc
Abstract
© 2022 Wiley-VCH GmbH.Here we report synthetic monosaccharide channels built with shape-persistent organic cages, porphyrin boxes (PBs), that allow facile transmembrane transport of glucose and fructose through their windows. PBs show a much higher transport rate for glucose and fructose over disaccharides such as sucrose, as evidenced by intravesicular enzyme assays and molecular dynamics simulations. The transport rate can be modulated by changing the length of the alkyl chains decorating the cage windows. Insertion of a linear pillar ligand into the cavity of PBs blocks the monosaccharide transport. In vitro cell experiment shows that PBs transport glucose across the living-cell membrane and enhance cell viability when the natural glucose transporter GLUT1 is blocked. Time-dependent live-cell imaging and MTT assays confirm the cyto-compatibility of PBs. The monosaccharide-selective transport ability of PBs is reminiscent of natural glucose transporters (GLUTs), which are crucial for numerous biological functions.
URI
https://pr.ibs.re.kr/handle/8788114/12453
DOI
10.1002/anie.202214326
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse