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복잡계 자기조립 연구단
복잡계 자기조립 연구단
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Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity

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Title
Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity
Author(s)
Junghong Park; Jihoon Kim; Kaushik Singha; Han, D.K.; Park, H.; Won Jong Kim
Publication Date
2013-11
Journal
BIOMATERIALS, v.34, no.34, pp.8766 - 8775
Publisher
ELSEVIER SCI LTD
Abstract
The work demonstrated a successful synthesis of nitric oxide (NO)-releasing material and its antibacterial effect on Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). The polymeric support composed of thermosensitive Pluronic F68 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. The developed F68eBPEIeNONOates releases a suf!cient amount of NO under physiological condition to elicit effective killing of E. coli, S. aureus and MRSA. The antibacterial ability of the released NO was compared to un- treated control or unmodi!ed F68 polymer by using confocal microscopy; F68eBPEIeNONOates demonstrated excellent antibacterial activity with in vitro low cytotoxicity. TEM investigation also revealed the destruction of bacteria membrane caused by NO. The effectiveness of F68eBPEIeNONOates against resistant strains such as MRSA provides a very simple but highly ef!cient strategy to combat drug-resistant bacterial infections.
URI
https://pr.ibs.re.kr/handle/8788114/1208
ISSN
0142-9612
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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