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Multifunctional Injectable Hydrogel for In Vivo Diagnostic and Therapeutic Applications

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Title
Multifunctional Injectable Hydrogel for In Vivo Diagnostic and Therapeutic Applications
Author(s)
Gi Doo Cha; Wang Hee Lee; Sung-Hyuk Sunwoo; Dayoung Kang; Taegyu Kang; Kyoung Won Cho; Minjeong Kim; Ok Kyu Park; Dongjun Jung; Jongha Lee; Seung Hong Choi; Taeghwan Hyeon; Dae-Hyeong Kim
Publication Date
2022-01
Journal
ACS NANO, v.16, no.1, pp.554 - 567
Publisher
AMER CHEMICAL SOC
Abstract
Injectable hydrogels show high potential for in vivo biomedical applications owing to their distinctive mode of administration into the human body. In this study, we propose a material design strategy for developing a multifunctional injectable hydrogel with good adhesiveness, stretchability, and bioresorbability. Its multifunctionality, whereupon multiple reactions occur simultaneously during its injection into the body without requiring energy stimuli and/or additives, was realized through meticulous engineering of bioresorbable precursors based on hydrogel chemistry. The multifunctional injectable hydrogel can be administered through a minimally invasive procedure, form a conformal adhesive interface with the target tissue, dynamically stretch along with the organ motions with minimal mechanical constraints, and be resorbed in vivo after a specific period. Further, the incorporation of functional nanomaterials into the hydrogel allows for various in vivo diagnostic and therapeutic applications, without compromising the original multifunctionality of the hydrogel. These features are verified through theranostic case studies on representative organs, including the skin, liver, heart, and bladder.
URI
https://pr.ibs.re.kr/handle/8788114/12068
DOI
10.1021/acsnano.1c07649
ISSN
1936-0851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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