BROWSE

Related Scientist

NANOMAT's photo.

NANOMAT
나노입자 연구단
more info

ITEM VIEW & DOWNLOAD

Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence

Cited 0 time in webofscience Cited 0 time in scopus
17 Viewed 0 Downloaded
Title
Myelin Content in Mild Traumatic Brain Injury Patients with Post-Concussion Syndrome: Quantitative Assessment with a Multidynamic Multiecho Sequence
Author(s)
Yoo, Roh-Eul; Seung Hong Choi; Youn, Sung-Won; Hwang, Moonjung; Kim, Eunkyung; Oh, Byung-Mo; Lee, Ji Ye; Hwang, Inpyeong; Kang, Koung Mi; Yun, Tae Jin; Kim, Ji-Hoon; Sohn, Chul-Ho
Publication Date
2022-02
Journal
KOREAN JOURNAL OF RADIOLOGY, v.23, no.2, pp.226 - 236
Publisher
KOREAN SOCIETY OF RADIOLOGY
Abstract
Objective: This study aimed to explore the myelin volume change in patients with mild traumatic brain injury (mTBI) with post-concussion syndrome (PCS) using a multidynamic multiecho (MDME) sequence and automatic whole-brain segmentation. Materials and Methods: Forty-one consecutive mTBI patients with PCS and 29 controls, who had undergone MRI including the MDME sequence between October 2016 and April 2018, were included. Myelin volume fraction (MVF) maps were derived from the MDME sequence. After three dimensional T1-based brain segmentation, the average MVF was analyzed at the bilateral cerebral white matter (WM), bilateral cerebral gray matter (GM), corpus callosum, and brainstem. The Mann-Whitney U-test was performed to compare MVF and myelin volume between patients with mTBI and controls. Myelin volume was correlated with neuropsychological test scores using the Spearman rank correlation test. Results: The average MVF at the bilateral cerebral WM was lower in mTBI patients with PCS (median [interquartile range], 25.2% [22.6%-26.4%]) than that in controls (26.8% [25.6%-27.8%]) (p = 0.004). The region-of-interest myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (1.87 cm(3) [1.70-2.05 cm(3)] vs. 2.21 cm(3) [1.86- 3.46 cm(3)]; p = 0.003) and brainstem (9.98 cm(3) [9.45-11.00 cm(3)] vs. 11.05 cm(3) [10.10-11.53 cm(3)]; p = 0.015). The total myelin volume was lower in mTBI patients with PCS than that in controls at the corpus callosum (0.45 cm(3) [0.39-0.48 cm(3)] vs. 0.48 cm(3) [0.45-0.54 cm(3)]; p = 0.004) and brainstem (1.45 cm(3) [1.28-1.59 cm(3)] vs. 1.54 cm(3) [1.42-1.67 cm(3)]; p = 0.042). No significant correlation was observed between myelin volume parameters and neuropsychological test scores, except for the total myelin volume at the bilateral cerebral WM and verbal learning test (delayed recall) (r = 0.425; p = 0.048). Conclusion: MVF quantified from the MDME sequence was decreased at the bilateral cerebral WM in mTBI patients with PCS. The total myelin volumes at the corpus callosum and brainstem were decreased in mTBI patients with PCS due to atrophic changes.
URI
https://pr.ibs.re.kr/handle/8788114/12058
DOI
10.3348/kjr.2021.0253
ISSN
1229-6929
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse