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HectoSTAR μLED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology

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Title
HectoSTAR μLED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology
Author(s)
Mihály Vöröslakos; Kanghwan Kim; Nathan Slager; Eunah Ko; Sungjin Oh; Saman S. Parizi; Blake Hendrix; John P. Seymour; Kensall D. Wise; György Buzsáki; AntoniFernández-Ruiz; Euisik Yoon
Publication Date
2022-06
Journal
Advanced Science, v.9, no.18
Publisher
John Wiley and Sons Inc
Abstract
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.Dynamic interactions within and across brain areas underlie behavioral and cognitive functions. To understand the basis of these processes, the activities of distributed local circuits inside the brain of a behaving animal must be synchronously recorded while the inputs to these circuits are precisely manipulated. Even though recent technological advances have enabled such large-scale recording capabilities, the development of the high-spatiotemporal-resolution and large-scale modulation techniques to accompany those recordings has lagged. A novel neural probe is presented in this work that enables simultaneous electrical monitoring and optogenetic manipulation of deep neuronal circuits at large scales with a high spatiotemporal resolution. The “hectoSTAR” micro-light-emitting-diode (μLED) optoelectrode features 256 recording electrodes and 128 stimulation μLEDs monolithically integrated on the surface of its four 30-µm thick silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. The use of this device in behaving mice for dissecting long-distance network interactions across cortical layers and hippocampal regions is demonstrated. The recording-and-stimulation capabilities hectoSTAR μLED optoelectrodes enables will open up new possibilities for the cellular and circuit-based investigation of brain functions in behaving animals.
URI
https://pr.ibs.re.kr/handle/8788114/11926
DOI
10.1002/advs.202105414
ISSN
2198-3844
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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