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HectoSTAR μLED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology

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dc.contributor.authorMihály Vöröslakos-
dc.contributor.authorKanghwan Kim-
dc.contributor.authorNathan Slager-
dc.contributor.authorEunah Ko-
dc.contributor.authorSungjin Oh-
dc.contributor.authorSaman S. Parizi-
dc.contributor.authorBlake Hendrix-
dc.contributor.authorJohn P. Seymour-
dc.contributor.authorKensall D. Wise-
dc.contributor.authorGyörgy Buzsáki-
dc.contributor.authorAntoniFernández-Ruiz-
dc.contributor.authorEuisik Yoon-
dc.date.accessioned2022-07-28T04:42:08Z-
dc.date.available2022-07-28T04:42:08Z-
dc.date.created2022-05-10-
dc.date.issued2022-06-
dc.identifier.issn2198-3844-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11926-
dc.description.abstract© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.Dynamic interactions within and across brain areas underlie behavioral and cognitive functions. To understand the basis of these processes, the activities of distributed local circuits inside the brain of a behaving animal must be synchronously recorded while the inputs to these circuits are precisely manipulated. Even though recent technological advances have enabled such large-scale recording capabilities, the development of the high-spatiotemporal-resolution and large-scale modulation techniques to accompany those recordings has lagged. A novel neural probe is presented in this work that enables simultaneous electrical monitoring and optogenetic manipulation of deep neuronal circuits at large scales with a high spatiotemporal resolution. The “hectoSTAR” micro-light-emitting-diode (μLED) optoelectrode features 256 recording electrodes and 128 stimulation μLEDs monolithically integrated on the surface of its four 30-µm thick silicon micro-needle shanks, covering a large volume with 1.3-mm × 0.9-mm cross-sectional area located as deep as 6 mm inside the brain. The use of this device in behaving mice for dissecting long-distance network interactions across cortical layers and hippocampal regions is demonstrated. The recording-and-stimulation capabilities hectoSTAR μLED optoelectrodes enables will open up new possibilities for the cellular and circuit-based investigation of brain functions in behaving animals.-
dc.language영어-
dc.publisherJohn Wiley and Sons Inc-
dc.titleHectoSTAR μLED Optoelectrodes for Large-Scale, High-Precision In Vivo Opto-Electrophysiology-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000784473400001-
dc.identifier.scopusid2-s2.0-85128534532-
dc.identifier.rimsid78109-
dc.contributor.affiliatedAuthorEuisik Yoon-
dc.identifier.doi10.1002/advs.202105414-
dc.identifier.bibliographicCitationAdvanced Science, v.9, no.18-
dc.relation.isPartOfAdvanced Science-
dc.citation.titleAdvanced Science-
dc.citation.volume9-
dc.citation.number18-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusLOCAL-FIELD POTENTIALS-
dc.subject.keywordPlusSILICON PROBES-
dc.subject.keywordPlusHIGH-DENSITY-
dc.subject.keywordPlusNEURAL CIRCUITS-
dc.subject.keywordPlusOPTICAL CONTROL-
dc.subject.keywordPlusPLACE CELLS-
dc.subject.keywordPlusREPLAY-
dc.subject.keywordPlusHIPPOCAMPUS-
dc.subject.keywordPlusSEQUENCES-
dc.subject.keywordPlusPERTURBATION-
dc.subject.keywordAuthoroptogenetics-
dc.subject.keywordAuthorμLED-
dc.subject.keywordAuthorlarge-scale optoelectrophysiology-
dc.subject.keywordAuthorneural probe-
dc.subject.keywordAuthorneuronal ensembles-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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