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나노입자 연구단
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Mesoporous silica-coated luminescent Eu3+ doped GdVO4 nanoparticles for multimodal imaging and drug delivery

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Title
Mesoporous silica-coated luminescent Eu3+ doped GdVO4 nanoparticles for multimodal imaging and drug delivery
Author(s)
Taeho Kim; Lee N.; Yong Il Park; Jangwon Kim; Kim J.; Lee E.Y.; Yi M.; Kim B.-G.; Taeg Hwan Hyeon; Yu T.; Na H.B.
Publication Date
2014
Journal
RSC ADVANCES, v.4, no.86, pp.45687 - 45695
Publisher
ROYAL SOC CHEMISTRY
Abstract
We describe a simple method for synthesizing mesoporous silica-coated luminescent europium-doped gadolinium vanadate (GdVO4:Eu3+@mSiO2) nanoparticles. Their biomedical applications as a potential imaging nanoprobe for both fluorescence imaging and magnetic resonance imaging (MRI) and as a simultaneous anti-cancer drug delivery vehicle are also discussed. Eu3+ doped GdVO4 nanoparticles exhibit strong red photoluminescence and the Gd3+ in GdVO4 can be used as a T1 contrast agent for MRI. T1-weighted MR contrast enhancement as well as sustained intracellular drug delivery can be achieved by the mesoporous silica layer coating onto a single nanoparticle. Enhanced T1 MR contrast was proven by relaxometric studies on water access to the paramagnetic core. GdVO4:Eu3+@mSiO2 nanoparticles as a new type of theragnostic (imaging and treatment) agent can provide new opportunities in a cancer treatment.
URI
https://pr.ibs.re.kr/handle/8788114/1181
ISSN
2046-2069
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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