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Durable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling

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dc.contributor.authorHyunseon Seo-
dc.contributor.authorSang Ihn Han-
dc.contributor.authorKang‐Il Song-
dc.contributor.authorDuhwan Seong-
dc.contributor.authorKyungwoo Lee-
dc.contributor.authorSun Hong Kim-
dc.contributor.authorTaesung Park-
dc.contributor.authorJa Hoon Koo-
dc.contributor.authorMikyung Shin-
dc.contributor.authorHyoung Won Baac-
dc.contributor.authorOk Kyu Park-
dc.contributor.authorSoong Ju Oh-
dc.contributor.authorHyung-Seop Han-
dc.contributor.authorHojeong Jeon-
dc.contributor.authorYu-Chan Kim-
dc.contributor.authorDae-Hyeong Kim-
dc.contributor.authorTaeghwan Hyeon-
dc.contributor.authorDonghee Son-
dc.date.accessioned2022-06-13T06:25:19Z-
dc.date.available2022-06-13T06:25:19Z-
dc.date.created2021-03-25-
dc.date.issued2021-05-
dc.identifier.issn0935-9648-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11762-
dc.description.abstractSoft neuroprosthetics that monitor signals from sensory neurons and deliver motor information can potentially replace damaged nerves. However, achieving long-term stability of devices interfacing peripheral nerves is challenging, since dynamic mechanical deformations in peripheral nerves cause material degradation in devices. Here, a durable and fatigue-resistant soft neuroprosthetic device is reported for bidirectional signaling on peripheral nerves. The neuroprosthetic device is made of a nanocomposite of gold nanoshell (AuNS)-coated silver (Ag) flakes dispersed in a tough, stretchable, and self-healing polymer (SHP). The dynamic self-healing property of the nanocomposite allows the percolation network of AuNS-coated flakes to rebuild after degradation. Therefore, its degraded electrical and mechanical performance by repetitive, irregular, and intense deformations at the device-nerve interface can be spontaneously self-recovered. When the device is implanted on a rat sciatic nerve, stable bidirectional signaling is obtained for over 5 weeks. Neural signals collected from a live walking rat using these neuroprosthetics are analyzed by a deep neural network to predict the joint position precisely. This result demonstrates that durable soft neuroprosthetics can facilitate collection and analysis of large-sized in vivo data for solving challenges in neurological disorders.-
dc.language영어-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleDurable and Fatigue-Resistant Soft Peripheral Neuroprosthetics for In Vivo Bidirectional Signaling-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000630445800001-
dc.identifier.scopusid2-s2.0-85102767271-
dc.identifier.rimsid75156-
dc.contributor.affiliatedAuthorSang Ihn Han-
dc.contributor.affiliatedAuthorJa Hoon Koo-
dc.contributor.affiliatedAuthorMikyung Shin-
dc.contributor.affiliatedAuthorOk Kyu Park-
dc.contributor.affiliatedAuthorDae-Hyeong Kim-
dc.contributor.affiliatedAuthorTaeghwan Hyeon-
dc.contributor.affiliatedAuthorDonghee Son-
dc.identifier.doi10.1002/adma.202007346-
dc.identifier.bibliographicCitationADVANCED MATERIALS, v.33, no.20-
dc.relation.isPartOfADVANCED MATERIALS-
dc.citation.titleADVANCED MATERIALS-
dc.citation.volume33-
dc.citation.number20-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordAuthorconducting nanocomposites-
dc.subject.keywordAuthorfatigue-resistant nanocomposites-
dc.subject.keywordAuthorin vivo bidirectional signaling-
dc.subject.keywordAuthorsoft peripheral neuroprosthetics-
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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