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Applications of inorganic nanoparticles as therapeutic agents

Cited 73 time in webofscience Cited 98 time in scopus
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Title
Applications of inorganic nanoparticles as therapeutic agents
Author(s)
Taeho Kim; Taeg Hwan Hyeon
Subject
Biological barrier, ; Cell functions, ; Delivery vehicle, ; Inorganic nanoparticle, ; Molecular levels, ; Molecular process, ; Targeted delivery, ; Therapeutic agents, ; Diagnosis, ; Nanoparticles, ; Nanostructured materials, ; Diseases
Publication Date
2014-01
Journal
NANOTECHNOLOGY, v.25, no.1, pp.12001
Publisher
IOP PUBLISHING LTD
Abstract
During the last decade, various functional nanostructured materials with interesting optical, magnetic, mechanical and chemical properties have been extensively applied to biomedical areas including imaging, diagnosis and therapy. In therapeutics, most research has focused on the application of nanoparticles as potential delivery vehicles for drugs and genes, because nanoparticles in the size range of 2-100 nm can interact with biological systems at the molecular level, and allow targeted delivery and passage through biological barriers. Recent investigations have even revealed that several kinds of nanomaterials are intrinsically therapeutic. Not only can they passively interact with cells, but they can also actively mediate molecular processes to regulate cell functions. This can be seen in the treatment of cancer via anti-angiogenic mechanisms as well as the treatment of neurodegenerative diseases by effectively controlling oxidative stress. This review will present recent applications of inorganic nanoparticles as therapeutic agents in the treatment of disease. © 2014 IOP Publishing Ltd.
URI
https://pr.ibs.re.kr/handle/8788114/1160
DOI
10.1088/0957-4484/25/1/012001
ISSN
0957-4484
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
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