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Cancer imaging: Lighting up tumours

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Title
Cancer imaging: Lighting up tumours
Author(s)
Daishun Ling; Michael J. Hackett; Taeg Hwan Hyeon
Publication Date
2014-02
Journal
NATURE MATERIALS, v.13, no.2, pp.122 - 124
Publisher
NATURE PUBLISHING GROUP
Abstract
Gao and colleagues have developed a polymeric, micelle-based nanoprobe that is highly responsive to both the angiogenic tumor vasculature and the extracellular pH. First, Gao and colleagues introduced tertiary amines with controlled hydrophobic substituents as ionizable hydrophobic blocks for the pH-sensitive core. Nanoprobes with different transition pH values can thus be achieved by using tertiary amino groups that protonate at a different pH. Subsequently the polymers were derivatized with hydrophobic fluorophores. At physiological pH, the monomers spontaneously assemble with the fluorophores oriented into the centre of the particle and in close proximity with each other. As a result of this, the fluorophores tend to silence each other by a process called fluorescence resonance energy transfer. As the particle navigates the body and enters the tumor site, the drop in pH begins to protonate the amines. The extremely high sensitivity makes these nanoprobes promising candidates for clinical tumor diagnosis.
URI
https://pr.ibs.re.kr/handle/8788114/1132
ISSN
1476-1122
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
Files in This Item:
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