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Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission

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Title
Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission
Author(s)
Matteo Moschetta; Jong-Young Lee; João Rodrigues; Alice Podestà; Omar Varvicchio; Jangyup Son; Yangjin Lee; Kwanpyo Kim; Gwan-Hyoung Lee; Fabio Benfenati; Mattia Bramini; Andrea Capasso
Publication Date
2021-01
Journal
Advanced biology, v.5, no.1
Publisher
Wiley-VCH GmbH
Abstract
Graphene is regarded as a viable bio-interface for neuroscience due to its biocompatibility and electrical conductivity, which would contribute to efficient neuronal network signaling. Here, monolayer graphene grown via chemical vapor deposition is treated with remote hydrogen plasma to demonstrate that hydrogenated graphene (HGr) fosters improved cell-to-cell communication with respect to pristine graphene in primary cortical neurons. When transferred to polyethylene terephthalate, HGr exhibits higher wettability than graphene (water contact angle of 83.7 degrees vs 40.7 degrees), while preserving electrical conductivity (approximate to 3 k Omega square (-1)). A rich and mature network is observed to develop onto HGr. The intrinsic excitability and firing properties of neurons plated onto HGr appears unaltered, while the basic passive and active membrane properties are fully preserved. The formation of excitatory synaptic connections increases in HGr with respect to pristine graphene, leading to a doubled miniature excitatory postsynaptic current frequency. This study supports the use of hydrogenation for tailoring graphene into an improved neuronal interface, indicating that wettability, more than electrical conductivity, is the key parameter to be controlled. The use of HGr can bring about a deeper understanding of neuronal behavior on artificial bio-interfaces and provide new insight for graphene-based biomedical applications.
URI
https://pr.ibs.re.kr/handle/8788114/11062
DOI
10.1002/adbi.202000177
ISSN
2701-0198
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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