BROWSE

Related Scientist

CN's photo.

CN
나노의학 연구단
more info

ITEM VIEW & DOWNLOAD

Hydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission

DC Field Value Language
dc.contributor.authorMatteo Moschetta-
dc.contributor.authorJong-Young Lee-
dc.contributor.authorJoão Rodrigues-
dc.contributor.authorAlice Podestà-
dc.contributor.authorOmar Varvicchio-
dc.contributor.authorJangyup Son-
dc.contributor.authorYangjin Lee-
dc.contributor.authorKwanpyo Kim-
dc.contributor.authorGwan-Hyoung Lee-
dc.contributor.authorFabio Benfenati-
dc.contributor.authorMattia Bramini-
dc.contributor.authorAndrea Capasso-
dc.date.accessioned2022-01-10T02:50:11Z-
dc.date.available2022-01-10T02:50:11Z-
dc.date.created2021-07-07-
dc.date.issued2021-01-
dc.identifier.issn2701-0198-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11062-
dc.description.abstractGraphene is regarded as a viable bio-interface for neuroscience due to its biocompatibility and electrical conductivity, which would contribute to efficient neuronal network signaling. Here, monolayer graphene grown via chemical vapor deposition is treated with remote hydrogen plasma to demonstrate that hydrogenated graphene (HGr) fosters improved cell-to-cell communication with respect to pristine graphene in primary cortical neurons. When transferred to polyethylene terephthalate, HGr exhibits higher wettability than graphene (water contact angle of 83.7 degrees vs 40.7 degrees), while preserving electrical conductivity (approximate to 3 k Omega square (-1)). A rich and mature network is observed to develop onto HGr. The intrinsic excitability and firing properties of neurons plated onto HGr appears unaltered, while the basic passive and active membrane properties are fully preserved. The formation of excitatory synaptic connections increases in HGr with respect to pristine graphene, leading to a doubled miniature excitatory postsynaptic current frequency. This study supports the use of hydrogenation for tailoring graphene into an improved neuronal interface, indicating that wettability, more than electrical conductivity, is the key parameter to be controlled. The use of HGr can bring about a deeper understanding of neuronal behavior on artificial bio-interfaces and provide new insight for graphene-based biomedical applications.-
dc.language영어-
dc.publisherWiley-VCH GmbH-
dc.titleHydrogenated Graphene Improves Neuronal Network Maturation and Excitatory Transmission-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000655685400005-
dc.identifier.scopusid2-s2.0-85108964552-
dc.identifier.rimsid75891-
dc.contributor.affiliatedAuthorYangjin Lee-
dc.contributor.affiliatedAuthorKwanpyo Kim-
dc.identifier.doi10.1002/adbi.202000177-
dc.identifier.bibliographicCitationAdvanced biology, v.5, no.1-
dc.relation.isPartOfAdvanced biology-
dc.citation.titleAdvanced biology-
dc.citation.volume5-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.subject.keywordPlusCHEMICAL-VAPOR-DEPOSITION-
dc.subject.keywordPlusCULTURED HIPPOCAMPAL-NEURONS-
dc.subject.keywordPlusCHALLENGES-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusBEHAVIOR-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusWATER-
dc.subject.keywordAuthor2D materials-
dc.subject.keywordAuthorhydrogenation-
dc.subject.keywordAuthorhydrophilicity-
dc.subject.keywordAuthorneurons-
dc.subject.keywordAuthorpoly(ethylene terephthalate)-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse