BROWSE

Related Scientist

CN's photo.

CN
나노의학 연구단
more info

ITEM VIEW & DOWNLOAD

A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid

Cited 0 time in webofscience Cited 0 time in scopus
75 Viewed 0 Downloaded
Title
A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid
Author(s)
Hojeong Yu; Hoyeon Lee; Jiyong Cheong; Sang Won Woo; Juhyun Oh; Hyun-Kyung Oh; Jae-Hyun Lee; Hui Zheng; Cesar M. Castro; Yeong-Eun Yoo; Min-Gon Kim; Jinwoo Cheon; Ralph Weissleder; Hakho Lee
Publication Date
2021-10-20
Journal
SCIENCE TRANSLATIONAL MEDICINE, v.13, no.616, pp.eabe2352
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Tetrahydrocannabinol (THC), the primary psychoactive ingredient of cannabis, impairs cognitive and motor function in a concentration-dependent fashion. Drug testing is commonly performed for employment and law enforcement purposes; however, available tests produce low-sensitive binary results (lateral flow assays) or have long turnaround (gas chromatography-mass spectrometry). To enable on-site THC quantification in minutes, we developed a rapid assay for oral THC analysis called EPOCH (express probe for on-site cannabis inhalation). EPOCH features distinctive sensor design such as a radial membrane and transmission optics, all contained in a compact cartridge. This integrated approach permitted assay completion within 5 min with a detection limit of 0.17 ng/ml THC, which is below the regulatory guideline (1 ng/ml). As a proof of concept for field testing, we applied EPOCH to assess oral fluid samples from cannabis users (n = 43) and controls (n = 43). EPOCH detected oral THC in all specimens from cannabis smokers (median concentration, 478 ng/ml) and THC-infused food consumers. Longitudinal monitoring showed a fast drop in THC concentrations within the first 6 hours of cannabis smoking (half-life, 1.4 hours).
URI
https://pr.ibs.re.kr/handle/8788114/11054
DOI
10.1126/scitranslmed.abe2352
ISSN
1946-6234
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse