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A rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid

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dc.contributor.authorHojeong Yu-
dc.contributor.authorHoyeon Lee-
dc.contributor.authorJiyong Cheong-
dc.contributor.authorSang Won Woo-
dc.contributor.authorJuhyun Oh-
dc.contributor.authorHyun-Kyung Oh-
dc.contributor.authorJae-Hyun Lee-
dc.contributor.authorHui Zheng-
dc.contributor.authorCesar M. Castro-
dc.contributor.authorYeong-Eun Yoo-
dc.contributor.authorMin-Gon Kim-
dc.contributor.authorJinwoo Cheon-
dc.contributor.authorRalph Weissleder-
dc.contributor.authorHakho Lee-
dc.date.accessioned2022-01-10T02:30:11Z-
dc.date.available2022-01-10T02:30:11Z-
dc.date.created2021-11-29-
dc.date.issued2021-10-20-
dc.identifier.issn1946-6234-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11054-
dc.description.abstractTetrahydrocannabinol (THC), the primary psychoactive ingredient of cannabis, impairs cognitive and motor function in a concentration-dependent fashion. Drug testing is commonly performed for employment and law enforcement purposes; however, available tests produce low-sensitive binary results (lateral flow assays) or have long turnaround (gas chromatography-mass spectrometry). To enable on-site THC quantification in minutes, we developed a rapid assay for oral THC analysis called EPOCH (express probe for on-site cannabis inhalation). EPOCH features distinctive sensor design such as a radial membrane and transmission optics, all contained in a compact cartridge. This integrated approach permitted assay completion within 5 min with a detection limit of 0.17 ng/ml THC, which is below the regulatory guideline (1 ng/ml). As a proof of concept for field testing, we applied EPOCH to assess oral fluid samples from cannabis users (n = 43) and controls (n = 43). EPOCH detected oral THC in all specimens from cannabis smokers (median concentration, 478 ng/ml) and THC-infused food consumers. Longitudinal monitoring showed a fast drop in THC concentrations within the first 6 hours of cannabis smoking (half-life, 1.4 hours).-
dc.language영어-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleA rapid assay provides on-site quantification of tetrahydrocannabinol in oral fluid-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000711835300001-
dc.identifier.scopusid2-s2.0-85120147750-
dc.identifier.rimsid76778-
dc.contributor.affiliatedAuthorHojeong Yu-
dc.contributor.affiliatedAuthorJiyong Cheong-
dc.contributor.affiliatedAuthorJae-Hyun Lee-
dc.contributor.affiliatedAuthorJinwoo Cheon-
dc.identifier.doi10.1126/scitranslmed.abe2352-
dc.identifier.bibliographicCitationSCIENCE TRANSLATIONAL MEDICINE, v.13, no.616, pp.eabe2352-
dc.relation.isPartOfSCIENCE TRANSLATIONAL MEDICINE-
dc.citation.titleSCIENCE TRANSLATIONAL MEDICINE-
dc.citation.volume13-
dc.citation.number616-
dc.citation.startPageeabe2352-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusMETABOLITES-
dc.subject.keywordPlusFREQUENT-
dc.subject.keywordPlusURINE-
dc.subject.keywordPlusEXPOSURE-
dc.subject.keywordPlusPHARMACOKINETIC PROPERTIES-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusCANNABIS SMOKE-
dc.subject.keywordPlusDELTA(9)-TETRAHYDROCANNABINOL-
dc.subject.keywordPlusBLOOD-
dc.subject.keywordPlusTHC-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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