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Paramagnetic inorganic nanoparticles as T1 MRI contrast agents

Cited 59 time in webofscience Cited 63 time in scopus
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Title
Paramagnetic inorganic nanoparticles as T1 MRI contrast agents
Author(s)
Soo Hong Lee; Byung Hyo Kim; Na H.B.; Taeg Hwan Hyeon
Subject
Biological process, ; Clinical application, ; Inorganic nanoparticle, ; MRI contrast agents, ; Multiple disciplines, ; Safety and efficiencies, ; Signal enhancement, ; Spherical nanoparticles, ; Biology, ; Magnetic resonance imaging, ; Medicine, ; Molecular imaging, ; Paramagnetism, ; Nanoparticles, ; gadolinium, ; iron oxide, ; manganese, ; manganese oxide, ; nanoparticle, ; nuclear magnetic resonance imaging agent, ; article, ; biomedical engineering, ; contrast enhancement, ; human, ; image enhancement, ; in vitro study, ; in vivo study, ; nuclear magnetic resonance imaging, ; priority journal
Publication Date
2014-03
Journal
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, v.6, no.2, pp.196 - 209
Publisher
WILEY-BLACKWELL
Abstract
Magnetic resonance imaging (MRI) is one of the most powerful molecular imaging techniques and can noninvasively visualize and quantify biological processes within the living organisms. The introduction of exogenous contrast agents has allowed specific visualization of biological targets as well as enhanced the sensitivity of MRI. Recently, paramagnetic inorganic nanoparticles showing positive T1 contrast effect have been investigated as T1 MRI contrast agents. Since the first trials of spherical nanoparticles of manganese oxide and gadolinium oxide, inorganic nanoparticles of various compositions and shapes have been used for in vivo and in vitro MRI because of their distinct signal enhancement in MR images. However, for clinical applications, important and complex issues such as safety and efficiency should be investigated by active research encompassing multiple disciplines, including chemistry, biology, biomedical engineering, and medicine. © 2013 Wiley Periodicals, Inc.
URI
https://pr.ibs.re.kr/handle/8788114/1103
DOI
10.1002/wnan.1243
ISSN
1939-5116
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
421. Paramagnetic inorganic nanoparticles as T1 MRI contrast agents.pdfDownload

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