BROWSE

Related Scientist

Researcher

복잡계 자기조립 연구단
복잡계 자기조립 연구단
more info

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Cited 78 time in webofscience Cited 0 time in scopus
538 Viewed 161 Downloaded
Title
Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy
Author(s)
Ran Namgung; Yeong Mi Lee; Jihoon Kim; Yuna Jang; Byung-Heon Lee; In-San Kim; Pandian Sokkar; Young Min Rhee; Allan S. Hoffman; Won Jong Kim
Publication Date
2014-05
Journal
NATURE COMMUNICATIONS, v.5, no., pp.3702 -
Publisher
NATURE PUBLISHING GROUP
Abstract
Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host–guest interactions between a polymer–cyclodextrin conjugate and a polymer–paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.
URI
http://pr.ibs.re.kr/handle/8788114/1030
DOI
10.1038/ncomms4702
ISSN
2041-1723
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
20_Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse