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Electrical characteristics of amyloid beta peptides in vertical junctions

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Title
Electrical characteristics of amyloid beta peptides in vertical junctions
Author(s)
Seo, Sohyeon; Lee, Jinju; Choi, Jungsue; G. Hwan Park; Yeseul Hong; Hyoyoung Lee
Publication Date
2021-07
Journal
NPG ASIA MATERIALS, v.13, no.1
Publisher
NATURE RESEARCH
Abstract
© 2021 Springer Nature Limited. Assembled amyloid beta (A beta) peptides have been considered pathological assemblies involved in human brain diseases, and the electron transfer or electron transport characteristics of A beta are important for the formation of structured assemblies. Here, we report the electrical characteristics of surface-assembled A beta peptides similar to those observed in Alzheimer's patients. These characteristics correlate to their electron transfer characteristics. Electrical current-voltage plots of A beta vertical junction devices show the A beta sequence dependence of the current densities at both A beta monomers (mono-A beta s) and A beta oligomers (oli-A beta s), while A beta sequence dependence is not clearly observed in the electrical characteristics of A beta planar field effect transistors (FETs). In particular, surface oligomerization of A beta peptides drastically decreases the activity of electron transfer, which presents a change in the electron transport pathway in the A beta vertical junctions. Electron transport at oli-A beta junctions is symmetric (tunneling/tunneling) due to the weak and voltage-independent coupling of the less redox-reactive oli-A beta to the contacts, while that at mono-A beta junctions is asymmetric (hopping/tunneling) due to redox levels of mono-A beta voltage-dependently coupled with contact electrodes. Consequently, through vertical junctions, the sequence- and conformation-dependent electrical characteristics of A beta s can reveal their electron transfer activities.
URI
https://pr.ibs.re.kr/handle/8788114/10074
DOI
10.1038/s41427-021-00321-z
ISSN
1884-4049
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > 1. Journal Papers (저널논문)
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