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Magnetothermally Activated Nanometer-level Modular Functional Group Grafting of Nanoparticles

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Title
Magnetothermally Activated Nanometer-level Modular Functional Group Grafting of Nanoparticles
Author(s)
Yongjun Lim; Seung-hyun Noh; Tae-Hyun Shin; Jung-uk Lee; Dominik Lungerich; Jae-Hyun Lee; Jinwoo Cheon
Publication Date
2021-04
Journal
NANO LETTERS, v.21, no.8, pp.3649 - 3656
Publisher
AMER CHEMICAL SOC
Abstract
Nanoparticles with multifunctionality and high colloidal stability are essential for biomedical applications. However, their use is often hindered by the formation of thick coating shells and/or nanoparticle agglomeration. Herein, we report a single nanoparticle coating strategy to form 1 nm polymeric shells with a variety of chemical functional groups and surface charges. Under exposure to alternating magnetic field, nanosecond thermal energy pulses trigger a polymerization in the region only a few nanometers from the magnetic nanoparticle (MNP) surface. Modular coatings containing functional groups, according to the respective choice of monomers, are possible. In addition, the surface charge can be tuned from negative through neutral to positive. We adopted a coating method for use in biomedical targeting studies where obtaining compact nanoparticles with the desired surface charge is critical. A single MNP with a zwitterionic charge can provide excellent colloidal stability and cell-specific targeting.
URI
https://pr.ibs.re.kr/handle/8788114/9952
DOI
10.1021/acs.nanolett.1c00770
ISSN
1530-6984
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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